Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most important antioxidants in the body.

Mar 4, 2025 · Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master regulator of cellular...

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative …

Nov 26, 2025 · Learn how Nrf2, the body’s master cellular defense switch, protects against stress, orchestrates detoxification, and supports long-term health.

Explore the NRF2 pathway's critical role in oxidative stress, inflammation, and chronic disease. Learn how NRF2 activation supports neuroprotection, cardiovascular health, and metabolic function—with …

Canonical Nrf2 activation refers to oxidation or electrophilic modification of the cysteine of KEAP1, resulting in conformational changes in the KEAP1–Nrf2 complex that prevent degradation of Nrf2 …

2 days ago · Background Lung cancer is one of the malignant tumors with high morbidity and mortality worldwide. Nuclear factor E2-ralated factor 2 (Nrf2), a critical antioxidant transcription factor, has …

Sep 29, 2021 · Nrf2 is present in an inactive state in the cytoplasm of cells. Its activation by internal or external stimuli, such as infections or pollution, leads to the transcription of more than 500 elements …

Dec 20, 2025 · The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in regulating cellular defense against oxidative stress and maintaining redox homeostasis. In the …

Jul 24, 2025 · Nrf2 (Nuclear factor erythroid 2-related factor 2) is a protein in the human body that plays a significant role in cellular defense. It acts as a sensor, detecting various forms of stress within cells …