A new crystal structure reveals the path taken by single-stranded (ss) DNA through the central channel of a hexameric helicase. The path resembles a spiral staircase and provides an answer to the ...

DEAD-box RNA helicases (DBRHs) modulate RNA secondary structure, allowing RNA molecules to adopt the conformations required for interaction with their target proteins. RH50 is a chloroplast-located ...

Helicase activity is required for scanning of the 40S ribosomal subunit, in a 5′ to 3′ direction, on the 5′ untranslated region (UTR) of eukaryotic mRNAs that contain secondary structures. The ...

Scientists have solved the structure of the Zika virus helicase, which is a key target for antiviral development. A team led by researchers from Tianjin University (P.R. China) has solved the ...

Scientists have successfully described a crucial structure involved in DNA replication, placing another piece in the puzzle of how life propagates. Scientists at Van Andel Research Institute and ...

This movie shows the helicase protein complex from all angles, and reveals how its shape changes back and forth between two forms. The research team hypothesizes that the rocking action of this ...

RNA helicases are a group of enzymes that bind to and alter RNA in an ATP-dependent way. They play significant roles in RNA metabolism, gene expression regulation, and innate immunity. Different RNA ...

DEAD-box helicases mediate local RNA destabilization and unwinding in all processes involving RNA. Figure 1: The conformational cycle of the DEAD-box helicase core is linked to duplex destabilization ...

These are two images showing the structure of the helicase protein complex from above. (a) A surface-rendered three-dimensional electron density map as obtained by cryo-EM. (b) A computer-generated ...

In a recent study published in the PNAS Journal, researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication. They characterized the ...

The structure of the Zika virus helicase, which is a key target for antiviral development has been solved by a team led by researchers from Tianjin University (P.R. China). The research is published ...

A team led by researchers from Tianjin University (P.R. China) has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in ...